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There have been anecdotal reports of an association between coelic disease and epilepsy with cerebral calcifications that resemble those of the Sturge-Weber syndrome.A series of patients who had epilepsy with calcifications that resemble those of the Sturge-Weber syndrome.A series of patients who had epilepsy with calcifications in whom coelic disease (CD)was incidentally observed,prompted us to study this association.43 patients(15 male,age range 4.6-30.7years)were selected from two series.31 patients with cerebral calcifications of unexplained origin and epilepsy (series A)underwent intestinal biopsy.12 patients with CD and epilepsy (series B)underwent computed tomography.Antibodies to gluten,folic acid serum concentrations,were measured,and HLA typing was done in most patients.24 of the series A patients were identified as having CD on the basis of a flat intestinal mucosa.(15/22 with a high concentration of serum antigluten),and 5 series B patients showed cerebral calcifications. giving a total of 29 cases with the combination o CD,epilepsy,and cerebral calcifications(CEC).In 27 of these CEC patients,calcifications were located in parieto-occipital regions.Only 2 of the series A patients had gastrointestinal symptoms at the time of intestinal biopsy;most patients had recurrent diarrhea,anaemia,and other symptoms suggestive of CD in the first three years of life.The epilepsy in CEC patients was poorly responsive to antiepileptic drugs.Gluten-free diet beneficially affected the course of epilepsy only when started soon after epilepsy onset.Cases of"atypical Sturge-Weber syndrome"(characterized by serpiginous cerebral calcifications and epilepsy without facial port-wine naevus)should be reviewed,and CD should be ruled out in all cases of epilepsy and cerebral calcifications of unexplained origin. |
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calcification,intracranial
CAT scan
CAT scan,abnormal
celiac disease,adult
celiac disease,childhood
celiac disease,epilepsy and cerebral calcification
seizure
seizure,children
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