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We report a 68-year-old man who received an IV inoculation of WBCs for an indium radionuclide scan containing 600 to 700 tissue culture infectious doses of human immunodeficiency virus type 1(HIV-1)from an HIV-1-infected individual.The recipient immediately received zidovudine,then was switched to dideoxyinosine and interferon-x,but died of hepatorenal syndrome and hepatic encephalopathy 15 days later.HIV-1 cultures were positive from the recipient's blood on day 14 but not days 0,1,and 8.At autopsy,cultures of parietal lobe isolated HIV-1,HIV-1 nucleic acid was present in several brain areas,but not in several other organs,by two independent laboratories,using the polymerase chain reaction.The brain showed mild perivascular cuffing and a mild lymphocytic meningitis,but there was no evidence of glial nodules,giant cells,or white matter abnormalities.HIV-1 gp41 viral antigen was seen by immunoperoxidase staining in rare infiltrating cells within perivascular and subpial spaces.Thus,HIV-1 was isolated from brain 15 days after mistaken HIV-1 inoculation and 1 day after virus was first recovered from blood. |
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