Click Here to return To Results

 

Identification of the Uncultured Bacillus of Whipple's Disease NEJM 327:293-301, 3461992., Relman,D.A.,et al, 1992 See this aricle in Pubmed Article Abstract A unique 1321-base bacterial 16S rRNA sequence was amplified from duodenal tissue of one patient.This sequence indicated the presence of a previously uncharacterized organism.We then detected this sequence in tissues from all 5 patients with Whipple's disease,but in none of those from 10 patients without the disorder.According to phylogenetic analysis,this bacterium is a gram-positive actinomycete that is not closely related to any known genus.Conclusions.We have identified the uncultured bacillus associated with Whipple's disease.The phylogenetic relations of this bacterium,its distinct morphologic characteristics,and the unusual features of the disease are sufficient grounds for naming this bacillus Tropheryma whippelii gen.nov.sp.nov.Our findings also provide a basis for a specific diagnostic test for this organism.

Related Tags

(click to filter results - removes previous filter) bacterial infection central nervous system,infection of neurologic disease,diagnoses of polymerase chain reaction Whipple's disease

Click Here to return To Results