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Three adult patients,two with undifferentiated connective tissue disease and one with carcinoma,had a distinctive pathologic reaction pattern consisting of necrotizing myopathy,minimal cellular infiltration and a microangiopathy with thick"pipestem"vessels and microvascular deposits of complement membrane attack complex.Quantitative analysis revealed focal capillary depletion.This pattern represents an immune-mediated microangiopathy and is distinct from that observed in other inflammatory myopathies. |
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