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Six patients(18%),two of whom were affected by systemic lupus erythematosus,had lupus anticoagulant.Plasminogen activator inhobotor activity was significantly higher in those positive for lupus than in those negative for lupus anticoagulant and control subjects(p<0.001).In young patients with stroke,lupus anticoagulant is associated with imbalance of the fibinolytic system as a result of higher levels of plasminogen activator inhibitor. |
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