Callosal Atrophy with Reduced Cortical Oxygen Metabolism in Carotid Artery Disease

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Callosal Atrophy with Reduced Cortical Oxygen Metabolism in Carotid Artery Disease
Stroke 24:88-93, Yamauchi,H.,et al, 1993 See this aricle in Pubmed

Article Abstract
Compared with 13 age-and sex-matched control subjects showing the same degree of white matter areas of high intensity,the patients had singificantly decreased callosal areas.The degree of corpus callosum atrophy was singificantly correlated with the mean cortical oxygen metabolic rate.The same tendency was also found in five patients without infarcts on computed tomography.However,neither the callosal area nor hemispheric metabolic rate was correlated with the extent of white matter lesions.These findings indicate that atrophy of the corpus callosum occurs in association with adecrease in cortical oxygen metabolism.Corpus callosum atrophy may be a useful morphological index that reflects cerebral cortical metabolic state in carotid artery occlusive disease. newabs CVD372 There were 250 incident cases of stroke identified,including 64 deaths with stroke listed as the underlying cause.The age-adjusted incidence rate of stroke among postmenopausal hormone ever-users was 82 per 10000 woman-years of follow-up compared with 124 per 10000 among never-users.Postmenopausal hormone use remained a protective factor against stroke incidence(relative risk,0.69;95%confidence interval,0.47 to 1.00)and stroke mortality(relative risk,0.37;95%confidence interval,0.14 to.92)after adjusting for the baseline risk factors of age,systolic blood pressure,diabetes,body mass index,smoking,history of hypertension and heart attack,and socioeconomic status.The results suggest that postmenopausal hormone use is associate with a decrease in the risk of stroke incidence and mortality in white postmenopausal women.

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