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With DNA extracted from brain specimens from 19 multiple sclerosis,5 progressive multifocal leukoencephalopathy,1 Alzheimer's disease,and 8 nonneurological control subjects,polymerase chain reaction was performed using nested sets of primer pairs amplifying segments of the large T and VP1 antigen-encoding sequences of JC virus.Both sequences were detected in each of the 5 brain specimens of progressive multifocal leukoencephalopathy but in none of the 19 multiple sclerosis,1 Alzheimer's disease,or the 8 control brain specimens. |
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