|
|
|
|
"Endozepines"are endogenous ligands for the benzodiaepine recognition sites on gamma aminobutyric acid A receptors in the nervous system. Idiopathic recurring stupor(IRS)is a syndrome of spontaneous stupor or coma that is not associated with known metabolic,toxic,or structural abnormalities but can be reversed by flumazenil,a pure benzo diazepine antagonist.We measured endozepine-2 and endozepine-4 by high performance liquid chromatography and radioceptor assay in serum and cerebrospinal fluid from three patients with IRS.During episodes of stupor there was a large(up to 300-fold compared with control patients)increase of endozepine-4 content in cerebrospinal fluid and serum,but a return to normal concentrations between attacks.Endozepine-4 may contribute to,or be the cause of IRS.The reasons for abnormal concentrations of endozepine in blood and brain are unknown. |
|