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Neurological Involvement in Wegener's Granulomatosis:An Analysis of 324 Consecutive Pts at the Mayo Clin
Neurol 33:4-9, Nishino,H.,et al, 1993
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Article Abstract
Neurological involvement in Wegener's granulomatosis was studied by reviewing the charts of 324 consecutive patients in whom the diagnosis was made at the Mayo Clinic.One hundred nine patients(33.6%)had neurological involvement.Peripheral neuropathy occurred in 53;cranial neuropathy,in 21; external ophthalmoplegia,in 16;cerebrovascular events,in 13;seizures,in 10;cerebritis,in 5;and miscellaneous involvement,in 25.The mean age and sex ratio were similar in the patients with and those without neurological involvement.Among the patients with peripheral neuropathy,42 had mononeuropathy multiplex;6,distal symmetrical polyneuropathy;and 5, unclassified peripheral neuropathy.Multiple mononeuropathy was a major presenting symptom in 8 patients.A significantly higher percentage of patients with peripheral neuropathy,compared to those without peripheral neuropathy,had kidney involvement(p<0.001).The second,sixth,and seventh cranial nerves were most frequently affected.Multiple cranial nerves were affected in 8 patients.Unusual neurological manifestations in the miscellaneous group were spastic paraparesis,temporal arteritis,Horner's syndrome,and papilledema.
 
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abducens nerve paralysis
arteritis,temporal
cerebritis
cerebrovascular accident
cranial neuropathy
cranial neuropathy,multiple
facial nerve palsy
granulomatosis with polyangiitis
headache
hearing loss
Horner's syndrome
intracerebral hemorrhage
mononeuropathy multiplex
neuropathy
neuropathy,vasculitic,systemic
ophthalmoplegia
optic nerve,lesion of
papilledema
paraparesis
paraparesis,spastic
review article
seizure
subarachnoid hemorrhage

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