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Acute Quadriplegic Myopathy:A Complic of Treat with Steroids, Nondepolarizing Blocking Agents, or Both Neurol 42:2082-2087, Hirano,M.,et al, 1992 See this aricle in Pubmed Article Abstract We studied two patients who were given high-dose intravenous steroid therapy and were intubated for status asthmaticus.Both became quadriplegic and wasted within 2 weeks.EMG had myopathic abnormalities.Muscle biopsy revealed severe atrophy of most muscle fibers,with disorganization of myofibrils and selective loss of thick(myosin)filaments.Immunohistologic stains for myosin isoforms confirmed the decrease or absence of this protein.Both patients clinically improved over several months.

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(click to filter results - removes previous filter) adverse drug reaction asthma drug induced neurologic disorders muscle biopsy myopathy myopathy,acute myopathy,critically ill myopathy,drug-induced myopathy,steroid induced neuromuscular blockade quadriplegia steroid steroid therapy,CNS treatment and complications with vecuronium

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