|
|
|
|
|
Click Here to return To Results
|
|
|
|
Hyperintense globus pallidus on T1-weighted MRI is present in most patients with advanced liver disease.We evaluated the relationship between the signal intensity of the globus pallidus and clinical or laboratory data of 77 patients eligible for liver transplantation.There was a significant correlation between the intensity of the signal and the Child- Pugh score(as indication of severity of liver disease),presence of postural tremor,previous episodes of variceal bleeding or hepatic encephalopathy,prothrombin activity,serum aspartate and alanine aminotransferase,bilirubin,and the indocyanine green(ICG)hepatic clearance,a very sensitive marker of liver function.The multivariate analysis disclosed that the ICG hepatic clearance and previous episodes of variceal bleeding were independently associated with the signal intensity in the globus pallidus.MRI repeated in 21 patients 10 to 20 months after transplant showed a disappearance of the lesion in all cases.We conclude that the hyperintense globus pallidus is secondary to the severity of the liver disease,and is reversible when liver function returns to normal. |
|
(click to filter results - removes previous filter)
basal ganglia
basal ganglia,lesion of
cirrhosis
globus pallidus
globus pallidus,lesion of
globus pallidus,lesion of,bilateral
hepatic encephalopathy
hepatic failure
liver disease
liver function enzymes
liver transplantation
MRI
MRI,abnormal
|
Click Here to return To Results
|
|