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Sixteen cases of hepatoma presenting as craniospinal metastasis without obvioushepatic involvement were reviewed.Metastatic spread of hepatoma to the cerebrum was found in one case,to the cranium in six cases,and to the vertebrae in nine cases.All of these cases had mildly abnormal liver function when first evaluated.Of those patients with hepatoma,56%had evidence of hepatomegaly.Alpha fetoprotein was present,at levels greater than320 ng/ml,in 69%.Ninety four per cent died of the primary liver disease within one year.For any patient who develops cranial metastasis of unknown origin in a geographical area where hepatoma is a common disease, hepatoma should be considered in the differential diagnosis. |
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carcinoma of liver hepatoma hepatomegaly life expectancy low back pain neoplasm,metastatic to base of skull neoplasm,metastatic to CNS neoplasm,metastatic to Dura pain,abdominal pain,back pain,buttock paraparesis prognosis radicular pain skull,metastatic carcinoma to spinal cord,compression of spine,metastasis to
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