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Three cases of disulfiram induced Parkinsonism and frontal lobe-like syndrome associated with bilateral lesions of the lentiform nuclei on CT scan are reported.Symptoms developed either after an acute high dose of disulfiram(one case)or after several days to weeks of disulfiram treatment (two cases)and persisted over several years in two patients.These observations suggest that basal ganglia are one of the major targets of disulfiram neurotoxicity.The mechanisms of the lesions of basal ganglia may involve carbon disulfide toxicity. |
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adverse drug reaction
basal ganglia
basal ganglia,lesion of
CAT scan
CAT scan,abnormal
disulfiram
encephalopathy
lenticular nucleus,lesion of
lenticular nucleus,lesion of,bilateral
movement disorder
movement disorder,drug induced
neurotoxin
Parkinson disease
Parkinson disease,drug induced
putamen,lesion of
putamen,lesion of,bilateral
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