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Prevention of First Occur of Neural-Tube Defects by Periconceptional Vitamin Suppl NEJM 327:1832-1835, 18751992., Czeizel,A.E.&Dudas,I., 1992 See this aricle in Pubmed Article Abstract Pregnancy was confirmed in 4753 women.The outcome of the pregnancy(whether the fetus or infant had a neural-tube defect or congenital malformation) was known in 2104 women who received the vitamin supplement and in 2052 who received the trace-element supplement.Congenital malformations were significantly more prevalent in the group receiving the trace-element supplement than in the vitamin-supplement group(22.9 per 1000 vs.13.3 per 1000,P=0.02).There were six cases of neural-tube defects in the group receiving the trace-element supplement,as compared with none in the vitamin-supplement group(P=0.029).The prevalence of cleft lip with or without cleft palate was not reduced by periconceptional vitamin supplementation.Periconceptional vitamin use decreases the incidence of a first occurrence of neural-tube defects.

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(click to filter results - removes previous filter) congenital malformation folic acid folic acid deficiency malformation,CNS,congenital neural tube defect prevention of neurologic disorders treatment of neurologic disorder vitamin supplementation vitamin,multiple

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