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Efficacy of Felbamate in Childhood Epileptic Encephalopathy (Lennox-Gestaut Syndrome) Felbamate Study Group in Lennox-Gestaut Synd, NEJM 328:29-331993., , 1993 See this aricle in Pubmed Article Abstract The patients treated with felbamate had a 34 percent decrease in the frequency of atonic seizures,as compared with a 9 percent decrease in the patients who received placebo(P=0.01).The felbamate-treated patients had a 19 percent decrease in the total frequency of seizures,as compared with a 4 percent increase in the placebo group(P=0.002).The global-evaluation scores were significantly higher in the felbamate group than in the placebo group from day 49 to the end of the study.There were no significant differences in the frequency of seizures occurring during video monitoring,but there was a significant reduction(P=0.017)in the number of tonic-clonic seizures during the maintenance period in the felbamate group.The types and frequency of side effects were similar in the two treatment groups.Felbamate is beneficial in patients with the Lennox-Gestaut syndrome.

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