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Global neuropsychological performance was significantly worse in the twins with more severe tic symptoms,with significant differences emerging on individual tests of attention,visuospatial perception,and motor function. In each twin pair,the twin with more severe tics had poorer global neuropsychological function.The results suggest that the nongenetic factors that influence tic severity in TS exert a similar effect on neuropsychological function,and that these two clinical manifestations of TS may share a common pathophysiologic state. |
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