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Hippocampal Atrophy in Normal Aging, An Association with Recent Memory Impairment
Arch Neurol 50:967-973, Golomb,J.,et al, 1993
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Article Abstract
Nearly 33%of the subjects had radiographic evidence for HA.The prevalence of HA increased significantly with age and was more common in male than female subjects.After controlling for age,level of education,and vocabulary,subjects with HA were found to perform more poorly on tests of recent(secondary)verbal memory when compared with subjects without HA(P<. 01).No significant differences were found for tests of immediate(primary) memory.We conclude that HA is a common accompaniment of normal aging and is associated with mild memory impairment.Additional research is needed to determine whether HA constitutes a significant risk for future dementia.
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