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Abnormal Cranial Magnetic Resonance Imaging Scans in Sickle-Cell Disease Arch Neurol 50:629-635, Kugler,S.,et al, 1993 See this aricle in Pubmed Article Abstract Cranial MRI abnormalities have important prognostic implications,even when detected in clinically asymptomatic patients.Cognitive abnormalities exist in patients with SCD even in the absence of MRI abnormalities or clinical stroke.

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