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Nature and Incidence of Peripheral Nerve Syndromes in HIV Infection
JNNP 56:372-381, Fuller,G.N.,et al, 1993
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Article Abstract
Fifty-four patients with peripheral nerve syndromes were seen during a 15 month period in a population of about 1500 HIV infected patients at all stages of the disease.Distal symmetrical peripheral neuropathies were seen in 38 of the 54 patients,(11-5%of AIDS patients)and could be distinguished into two forms.The most common(n=25)was a painful peripheral neuropathy during AIDS,which is distinct clinically and pathologically,having axonal atrophy,and is associated with cytomegalovirus infection at other sites. The 13 non-painful neuropathies seen were more heterogenous.Lumbosacral polyradiculopathy associated with cytomegalovirus and lymphomatous mononeuritis multiplex occurred in fewer than 1%of AIDS patients. Mononeuropathies were seen in 3%of AIDS patients.No patients with acute or chronic inflammatory demyelinating polyradiculoneuropathies were seen.The annual incidence of neuropathies during the AIDS-related complex stage was less than 1%;none were seen in asymptomatic HIV seropositive patients.
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acquired immunodeficiency syndrome
cytomegalovirus infection
human immunodeficiency virus type 1
lumbosacral plexus
lumbosacral plexus,neuritis
lymphoma
mononeuropathy multiplex
neuropathy
neuropathy,painful
peripheral nerve,lesion of
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