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No significant correlations were found between changes in headache score and blood level of drug or change in any of the physiologic measurements. Amitriptyline significantly reduced the severity,frequency,and duration of headache attacks;propranolol reduced the severity of attacks only. Amitriptyline response was correlated with female gender and baseline headaches of shortest duration and of highest frequency.Propranolol response was associated with attacks of greatest duration at baseline and with low pulse rise with exercise at baseline.Nonspecific response was associated with male gender and most frequent headaches by history. |
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