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We examined CSF for Borrelia burgdorferi antigens using antigen-capture ELISA and Western(immune)blot.Antigen-capture ELISA was positive in 38 of 77(49%)CSF samples obtained from neurologic patients with presumed B burgdorferi infection,compared with one of 34(3%)CSF samples obtained from other neurologic disease controls who came from a region endemic for Lyme disease.Western immunoblot was positive for B burgdorferi antigens in 12 of 22(55%)CSF samples from the B burgdorferi infected groups,compared with none of the 11 CSF samples from the control group.CSF antigen detection should prove helpful in evaluating patients for suspected neurologic Lyme disease. |
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