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We found significantly lower neuropsychological performance and cerebral blood flow in the patients with MD compared with the controls.Patients with mMD had statistically lower scores in IQ tests and more extensive cerebral hypoperfusion when compared with those with pMD.Changes in cerebral blood flow were most severe in the frontal and temporoparietal association cortex.Cerebral blood flow measures strongly correlated with IQ.Patients with mMD had earlier onset of disease and lower IQs than the pMD group.The pattern of cerebral perfusion in the mMD group was consistent with a diffuse brain injury,while cerebral perfusion in pMD showed more minor changes.These findings emphasize the cognitive differences between mMD and pMD. |
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