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Only two patients experienced major side effects,psychotic depression in one and acute pancreatitis in the other.Both of these patients were from the intravenous methylprednisolone group and both of the side effects resolved without sequelae.Patients in both groups receiving active drugs more often reported sleep disturbances,mood change,stomach upset,and facial flushing and gained more weight during the treatment period than patients in the placebo group(P<.001 for each comparison).Although minor side effects are common,short-term glucocorticoid therapy in young,healthy adults is relatively safe.Because of the infrequency of serious side effects,outpatient administration of high-dose intravenous glucocorticoids may be feasible. |
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