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During a mean follow-up of 1.9 years(a period during which 90 percent of febrile seizures recur),our intention-to-treat analysis showed a reduction of 44 percent in the risk of febrile seizures per person-year with diazepam(relative risk=0.56;95 percent confidence interval,0.38 to 0.81;P= 0.002).A survival analysis of the length of time to the first recurrent febrile seizure did not show a significant difference between the treatment groups(P=0.064 by the log-rank test),but after adjustment for covariates,diazepam was found to have a benefit(P=0.027 by Cox regression analysis).An analysis restricted to children who had seizures while actually receiving the study medication(7 in the diazepam group and 29 in the placebo group)showed an 82 percent reduction in the risk of febrile seizures with diazepam(relative risk=0.18;95 percent confidence interval, 0.99 to 0.37;P<0.001).Of the 153 children who took at least one dose of diazepam,39 percent had ataxia,lethargy,or irritability or at least one other moderate side effect that was reversed after a reduction in the dose.There were no severe side effects. |
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children
fever
prevention of neurologic disorders
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seizure,children
seizure,febrile
seizure,prevention of
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treatment of neurologic disorder
valium
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