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Serum lipid levels change during carbamazepine medication;the increase in serum concentrations of total cholesterol and high-density lipoprotein cholesterol seems permanent,but the increase in serum low-density lipoprotein cholesterol and triglyceride levels is transient.The change in lipid metabolism may be associated with induction of the liver enzymes during carbamazepine medication.The increase in serum cholesterol and high-density lipoprotein cholesterol levels may have clinical relevance with regard to the incidence of atherosclerosis and coronary heart disease in patients with epilepsy receiving carbamazepine medication. |
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