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Of 36 patients,17 were male,with a mean age of 28 years.Mean age for women was 25 years.Nine patients(25%;5 women,4 men)had a deficiency of one natural anticoagulant and constituted group I.In these patients,isolated protein S deficiency was detected in five cases(13.8%);in one case,we observed the association between protein S deficiency and antiphospholipid antibodies;and deficiency of protein C was seen in one case(2.7%),of antithrombin III in one case(2.7%),and of plasminogen in one case(2.7%). Instances of cerebral infarction without natural anticoagulation deficiency(group II)included 12 women and 15 men.There were no differences in clinical and radiological findings between the two groups.Considering the importance of prothrombotic state,especially caused by deficiency of protein S,in the development of cerebral infarcts,we suggest that it should be looked for in every young patient affected by this pathological entity and in whom no etiologic factors can be determined. |
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