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4-Aminopyridine in the Treatment of Patients with Multiple Sclerosis:Long-term Efficacy and Safety Arch Neurol 51:292-296, Polman,C.H.,et al, 1994 See this aricle in Pubmed Article Abstract Twenty of 23 patients who showed a favorable initial response benefited from long-term administration.Ambulation and fatigue(each in 13 patients) and visual function(in five patients)were most frequently reported to be improved.Three major side effects did occur during a follow-up of 406 patient months:a generalized epileptic seizure in two patients and hepatitis in one.Although a substantial proportion of patients with multiple sclerosis seem to benefit from long-term administration of 4- aminopyridine,additional studies are needed to clarify the exact value of the drug.

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(click to filter results - removes previous filter) adverse drug reaction aminopyridine,4 multiple sclerosis multiple sclerosis,treatment of treatment of neurologic disorder

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