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When compared with patients in the Clinical Dementia Rating stages 3 and 4,patients with a stage 5 scored significantly lower on the Glasgow Coma Scale,with the discriminating subscales being verbal and motor responses. Primitive reflexes,myoclonus,and dyskinesia were increasingly prevalent in the more terminal stages.Cognitive screening assessments did not discriminate between groups.Rudimentary neurologic functions can be readily assessed and,when viewed together with the Glasgow Coma Scale,may circumvent the"floor effect"frequently encountered when using the currently available cognitive and functional scales and,thereby,better define patients with end-stage Alzheimer's disease. |
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