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Relation of Alcoholic Myopathy to Cardiomyopathy Ann Int Med 120:529-536, Fernandez-Sola,J.,et al, 1994 See this aricle in Pubmed Article Abstract Alcoholic patients with cardiomyopathy had less muscle strength than did alcoholic patients with normal cardiac function,patients with idiopathic dilated cardiomyopathy,and patients with coronary heart disease(all P<0. 01).Among alcoholic patients with cardiomyopathy,20 of 24(83%)had histologic findings of skeletal myopathy compared with 1 of 24(4%) alcoholic patients with normal cardiac function(P<0.001).Interstitial fibrosis occurred in all cardiac biopsy speciments,hypertrophy of the myocytes occurred in 95%,and myocytolysis occurred in 83%.Those patients with more severe cellular hypertrophy and interstitial fibrosis of the myocardium had a greater decrease in deltoid muscle strength and had worse histologic myopathy.Diseases of skeletal and cardiac muscle in patients with chronic alcoholism are clinically and histologically related.The presence of muscle weakness in an alcoholic person suggests the likelihood of an accompanying cardiomyopathic abnormality.

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