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Idiopathic Autonomic Neuropathy:Clinical Neurophysiologic, and Follow-up Studies on 27 Patients
Neurol 44:1675-1682, Suarez,G.A.,et al, 1994
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Article Abstract
We evaluated the natural history,electrophysiologic characteristics, spectrum of autonomic involvement,pathology and laboratory features in 27 patients with idiopathic autonomic neuropathy who were followed up for a mean of 32 months.The typical features of idiopathic autonomic neuropathy include the absence of an associated disease,frequent history of preceding infection,and acute or subacute onset with a monophasic course.The spectrum of autonomic involvements ranges from panautonomic to selective adrenergic or cholinergic failure.There is infrequent involvement of somatic nerve fibers as assessed by routine nerve conduction studies. Pathologic features include the presence of a small inflammatory mononuclear cell infiltrate in the epineurium.Recovery tends to be gradual and frequently incomplete.The acute onset,frequent antecedent viral infection,selectivity of involvement by fiber type and autonomic level,and presence of perivascular mononuclear cell infiltration suggest that the underlying mechanism is likely to be immune-mediated.These observations may justify plasma exchange or other immunosuppressive modalities as early therapeutic intervention in patients with progressive disability.
 
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autonomic dysfunction
autonomic neuropathy
autonomic neuropathy,idiopathic
Guillain Barre syndrome
neuropathy
prognosis
review article
treatment of neurologic disorder
viral infection

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