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Initial and Follow-up Brain MRI Findings and Correlation with the Clinical Course in Wilson's Disease Neurol 44:1064-1068, Roh,J.K.,et al, 1994 See this aricle in Pubmed Article Abstract We performed pretreatment brain MRIs in 25 patients with neurologically symptomatic Wilson's disease(WD)and clinical MRI follow-up in 16 of them. All 25 pretreatment MRIs revealed abnormalities,with abnormal high-signal intensity(HSI)in bilateral thalami being the most common(92%).HSI lesions in the brainstem(84%)and the basal ganglia(72%)were also common.Brain atrophy was present in 88%of the 25 patients.In the follow-up period of 5 to 24 months,during which patients were treated with D-penicillamine,both HSI lesions and neurologic symptoms improved in 88%of the 16 patients,but the brain atrophy did not change.

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