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Chronic progressive multiple sclerosis(MS)is a severely disabling demyelinating disease in which autoimmune processes seem to have a major role.The nucleoside drug cladribine is a potent lympholytic agent with few side-effects.We have studied it efficacy and safety in a randomized double-blind trial.Cladribine was generally well tolerated and clinically significant toxicity occurred in only 1 patient,in whom severe marrow suppression developed with complete recovery after several months.1 patient died of newly acquired hepatitis B,an event unlikely to be related to cladribine.We conclude that the immunosuppressive drug cladribine influences favorably the course of chronic progressive MS. |
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