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Increased Risk of Alzheimer's Disease in Mothers of Adults with Down's Syndrome Lancet 344:353-356, Schupf,N.,et al, 1994 See this aricle in Pubmed Article Abstract There was an increase in risk of dementia among mothers of DS probands compared with control mothers(risk ratio 2:6[95%CI 0:9-7:3]).The risk of dementia among mothers were who 35 or younger when their DS children were born was 5 times that of control mothers(4:0[1:6-15:4]).There was no increase in risk of dementia among mothers who were older(<35 years)at the proband's birth(0:8[2-3:4]).There was no difference in risk of dementia between fathers of DS cases and fathers of controls(1:2[0:4-3:9])and no discernible influence of age on this risk.Familial aggregation of dementia among mothers of adults with DS supports the hypothesis of a shared genetic susceptibility to DS and AD.

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