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Anti-Ro (SS-A) Autoantibodies in CNS Disease Assoc with Sjogren's Synd (CNS-SS) :Clin, Neuroimaging & Angiographic Correl
Neurol 44:899-908, Alexander,E.L.,et al, 1994
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Article Abstract
Precipitating antibodies against the Ro(SS-A)antigen,determined by gel double-immunodiffusion,were present in an increased frequency in CNS-SS patients with(1)documented clinical CNS disease,(2)focal clinical CNS manifestations and serious complications,(3)large regions of increased signal intensity,consistent with ischemia/infarcts on brain MRI scans or regions of decreased attenuation consistent with infarcts on CT,and(4) abnormal cerebral angiograms consistent with small-vessel angiitis. Finally,the anti-Ro(SS-A)antibody response in CNS was directed against the 60-kd peptide specificity,determined by ELISA.Clinical,neuroimaging (cerebral CT)and angiographic observation suggest that a subset of anti-Ro (SS-A)antibody-positive,in contrast with negative,CNS-SS patients have more serious and extensive CNS disease,some with frank cerebral angiopathy.Anti-Ro(SS-A)antibodies are postulated to play a role in mediating or potentiating vascular injury in CNS-SS.
 
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angiography,cerebral
anti Ro antibody
arteriopathy
autoantibodies
MRI
MRI,abnormal
Sjogren's syndrome
Sjogren's syndrome,neurologic manifestations of
vasculopathy

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