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Alzheimer's disease case patients were significantly less likely than control subjects to use estrogen replacement(7%vs 18%),but groups did not differ with regard to the total number of prescription medications or to the most frequently prescribed class of drug(thyroid medication).Demented case patients using estrogen did not differ significantly from those not using estrogen in terms of age,education,or symptom duration,but their mean performance on a cognitive screening instrument was significantly better(Mini-Mental State examination scores of 14.9 vs 6.5).Findings are consistent with contentions that postmenopausal estrogen replacement therapy may be associated with a decreased risk of AD and that estrogen replacement may improve cognitive performance of women with this illness. |
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