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From 2.2 through 7 years,boys with fragile X have significantly larger mean testicular volumes than boys without fragile X,but macroorchidism(>/= 4.0 mL or>/=2 times normal)only occurred in 1 of 27 boys with fragile X. From 8 to 10 years,all our patients with fragile X had clinically enlarged testicles(>/=3.75 mL),and 7 of 9 boys with fragile X had macroorchidism (>/=mL).The testicular volumes of control subjects were all=3.0 mL.These findings suggest that macroorchidism occurs in some prepubertal boys with fragile X,but in this series it did not occur until age 6 and usually did not occur until after age 8. |
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