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Pituitary Magnetic Resonance Imaging in Normal Human Volunteers:Occult Adenomas in General Population Ann Int Med 120:817-820, Hall,W.A.,et al, 1994 See this aricle in Pubmed Article Abstract Seven women(10%)and three men(10%)had focal areas of decreased signal intensity in the pituitary gland after administration of Gd-DTPA.The lesions ranged from 3 to 6 mm in greatest diameter and were diagnosed as pituitary adenomas by at least two of the three reviewers.When similar lesions were detected on MRI scans in patients with Cushing disease,the positive predictive value for identification of an adenoma at that site was 86%.About 10%of the normal adult population have pituitary abnormalities on MRI scans that are compatible with the diagnosis of asymptomatic pituitary adenomas.Most pituitary adenomas remain asymptomatic and do not require treatment.

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