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Seizures recurred in 53 patients(40%).The mean duration of followup was 39 months(range,11 to 105)for the patients who did not have a recurrence of seizures.Neither the length of the taper period(six weeks vs nine months, p=0.,38),nor the length of time the patients were free of seizures before the taper period was begun(two years vs four years,p=0.20)significantly influenced the risk of seizure recurrence.The presence of mental retardation(relative risk 3.1;95 percent confidence interval 1.5 to 6.2)or spikes in the EEG at the time of tapering(relative risk 1.9;95 percent confidence interval,1.0 to 3.4)increased the risk of seizure recurrence. The risk of seizure recurrence during drug tapering and after the discontinuation of antiepileptic drug therapy in children with epilepsy is not different whether the medications are tapered over a six week or a nine month period. |
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anticonvulsants,discontinuation in seizure-free epileptics
drug withdrawal
risk factors
seizure
seizure,children
seizure,prognosis in childhood
seizure,risk factors for
seizure,treatment of
treatment of neurologic disorder
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