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Cerebellar Atrophy in Patients with Long-Term Phenytoin Exposure and Epilepsy Arch Neurol 51:767-771, Ney,G.C.,et al, 1994 See this aricle in Pubmed Article Abstract The magnetic resonance imaging scans were reviewed in a blind fashion.A rating was assigned to each scan based on the degree of cerebellar atrophy.Cerebellar atrophy was significantly more pronounced in patients than in controls.No correlation was found between cerebellar atrophy and variables reflective of seizure severity or degree of phenytoid exposure. Cerebellar atrophy may be seen in phenytoid-exposed patients with epilepsy in the absence of generalized tonic-clonic seizures or preexistent brain damage.Whether it is the phenytoin or the seizures that play the primary etiologic role remains unanswered.These factors may be synergistic.

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