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Progressive Cerebral Occlusive Disease after Radiation Therapy Stroke 26:131-136, Bitzer,M.&Topka,H., 1995 See this aricle in Pubmed Article Abstract A 19 year old woman presented with recurrent ischemic brain lesions after radiation therapy for treatment of a craniopharyngioma during childhood. Cerebral angiography 6 and 12 years after completion of radiation therapy revealed progressive cerebral arterial occlusive disease involving the internal carotid artery on either side of the circle of Willis,with abnormal netlike vessels and transdural anastomoses(moyamoya syndrome). Extensive similarities between irradiation-induced cerebral vasculopathy and primary moyamoya syndrome(Nishimoto's disease)support the notion that both disorders share common pathophysiological mechanisms.The occurrence of moyamoya-like vascular changes may not depend on specific trigger mechanisms but may rather represent a nonspecific response of the developing vascular system to a number of various noxious events.

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(click to filter results - removes previous filter) angiography,cerebral arteriopathy carotid artery occlusion,intracranial carotid artery stenosis,intracranial cerebral ischemia cerebrovascular accident moyamoya moyamoya,adult radiation therapy,CNS treatment and complications with radiation vasculopathy seizure transient ischemic attack vasculopathy

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