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To determine the frequency,spectrum,and clinical features of neurologic disorders associated with ulcerative colitis(UC)and Crohn's disease(CD). Three percent of IBD patients had neurologic involvement.In 14 of 19(74%), it started within a mean of 5.7 years(range,0.7 to 12 years)after the diagnosis of bowel disease,and in two of 19(10%)it occurred at the time of IBD exacerbation.During the course of IBD,10 of 19 patients(53%)exhibited other extraintestinal manifestations.Peripheral nerve disorders were observed in six UC patients.Myelopathy(5 patients),myopathy(3),and myasthenia gravis(1)were diagnosed in eight CD patients and one UC patient.Cerebrovascular disorders occurred in two UC and two CD patients. Neurologic disorders associated with IBD are more common than appreciated and follow a different pattern of involvement in UC and CD.A prospective study is required to define the nature of this association. |
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