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To our knowledge,ours represents the first neuropathologic description of a patient with Williams syndrome.Although Williams syndrome is usually sporadic,familial cases have been reported along with candidate chromosomal loci.If our findings are confirmed in additional patients with Williams syndrome,they may provide cause to other factors that are important in the pathogenesis of senile plaques(with B/A4 amyloid deposition)and neurofibrillary tangles. |
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