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The Natural History of the Pituitary Incidentaloma Arch Int Med 155:181-183, Donovan,L.E.&Corenblum,B., 1995 See this aricle in Pubmed Article Abstract Only patients with pituitary incidentalomas greater than 10 mm in greatest diameter developed tumor enlargement or complications.Three patients developed symptomatic tumor enlargement.In four patients,masses decreased in size.Only two patients developed complications.One required subsequent surgery.The only permanent impairment was panhypopituitarism following surgery in this patient.Patients with pituitary incidentalomas of unknown causes usually follow a benign course for at least 6 years after discovery.Neurosurgical intervention is not initially required in the management of pituitary incidentalomas,particularly those less than 10 mm, as long as clinical observation can be continued.

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