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Ischemic Stroke in Young Pts with Activated Protein C Resistance:Rpt of Three Cases Belonging to Three Different Kindreds
Stroke 26:885-890, Simioni,P.,et al, 1995
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Article Abstract
A new pathological condition termed"activated protein C(APC)resistance"has recently been reported to be the most common hereditary blood coagulation disorder associated with familial thrombosis.APC resistance is characterized by a poor anticoagulant response to APC in the plasma of patients and is due to a defect of factor V.This report deals with three Italian families with inherited APC resistance in which stroke had occurred at a young age in one of the family members.The cases reported here suggest a possible association of inherited APC resistance with ischemic stroke in young patients.Case-control studies should be performed to assess the true association.
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activated protein C resistance
cerebrovascular accident
cerebrovascular accident,familial occurrence
cerebrovascular accident,young adult
Factor V Leiden
factor V,deficiency
familial
genetic neurologic disorders
MRI
MRI,abnormal
thrombophlebitis
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