|
|
|
|
Neuron-specific enolase(NSE)is among the biochemical markers in cerebrospinal fluid reported to be useful in the differential diagnosis of Creutzfeldt-Jakob disease from other dementing illnesses.In a group of 58 patients with definite and probable Creutzfeldt-Jakob disease,NSE concentrations(median 94.0,interquartile range 256 ng/mL)were significantly higher(p<0.001)than in 26 control patients(9.5,15.5 ng/mL). At a cut-off of 35 ng/mL an optimum sensitivity of 80%with a specificity of 92%for the diagnosis of Creutzfeldt-Jakob disease by NSE in cerebrospinal fluid was obtained. |
|