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Neuropath Evid of Graft Survival & Striatal Reinnerva after Transpl of Fetal Mesencephalic Tissue in Parkinson's Dis NEJM 332:1118-1124, 11631995., Kordower,J.H.,et al, 1995 See this aricle in Pubmed Article Abstract After transplantation,the patient had sustained improvement in motor function and a progressive increase in fluorodopa uptake in the putamen on PET.On examination of the brain,each of the large grafts appeared to be viable.Each was integrated into the host striatum and contained dense clusters of dopaminergic neurons.Processes from these neurons had grown out of the grafts and provided extensive dopaminergic reinnervation to the striatum in a patch-matrix pattern.Ungrafted regions of the putamen showed sparse dopaminergic innervation.We could not identify any sprouting of host dopaminergic processes.Grafts of fetal mesencephalic tissue can survive for a long period in the human brain and restore dopaminergic innervation to the striatum in patients with Parkinson's disease.In the patient we studied,clinical improvement and enhanced fluorodopa uptake on PET scanning were associated with the survival of the grafts and dopaminergic reinnervation of the striatum.

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(click to filter results - removes previous filter) brain transplantation CAT scan,emission CAT scan,emission,abnormal fetal tissue neuropathology Parkinson disease Parkinson disease,surgical treatment of Parkinson disease,treatment of prognosis substantia nigra tissue

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