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PET Studies on the Dopaminergic Sys & Striatal Opioid Binding in the OPCA Variant of Multiple System Atrophy Ann Neurol 37:568-573, Rinne,J.O.,et al, 1995 See this aricle in Pubmed Article Abstract Ten patients with sporadic olivopontocerebellar atrophy and autonomic failure were studies with positron emission tomography.Subjects underwent both an{11C}diprenorphine and an{18F}fluorodopa scan.The mean caudate- occipital uptake ration for{11C}diprenorphine was significantly reduced to 88%and the putamen-occipital uptake ratio to 85%of the control values. Individually,4 of the 10 patients had significantly reduced opioid binding in the putamen.Mean putamen{18F}fluorodopa uptake was significantly diminished(to 71%of the control mean);individually 7 patients had significantly reduced uptake.There was a significant positive correlation between putamen-occipital uptake rations for{11C}diprenorphine and putamen uptake of{18F}fluorodopa.Our results suggest that subclinical nigrostriatal dysfunction is present in the majority of patients with sporadic olivopontocerebellar atrophy,in accordance with it being part of the spectrum of multiple system atrophy.

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(click to filter results - removes previous filter) CAT scan CAT scan,emission CAT scan,emission,abnormal multiple system atrophy spinocerebellar ataxia type 1

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