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A 54-year-old woman presenting with seizures,headache,and changes in mental status was found to have vascular narrowing in cerebral blood vessels and ischemic lesions on neuroimaging studies of the brain, interpreted as cerebral vasculitis.A brain biopsy showed leptomeningeal glioma.Postmortem examination demonstrated a glioblastoma arising around the right sylvian fissure with extensive subarachnoid dissemination of tumor.The leptomeningeal tumor caused vascular narrowing by encasement, direct vascular wall invasion,and thrombosis and was associated with underlying infarctlike foci of parenchymal necrosis.This case demonstrates an unusual presentation of glioblastoma clinically and radiographically mimicking cerebral vasculitis,and it illustrates a variety of mechanisms for tumor-produced vascular compromise. |
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angiitis angiography, cerebral, beaded vessels angiography,cerebral CAT scan CAT scan,abnormal cerebrospinal fluid,abnormal cerebrospinal gliomatosis glioblastoma multiforme(astrocytoma Gr.III) glioma gliomatosis cerebri meningeal gliomatosis MRI MRI,abnormal neuropathology vasculitides
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