|
|
|
|
In the case patients,prominent clinical features were subacute loss of visual acuity with field defects,diminished color vision,optic-nerve pallor and decreased sensitivity to vibration and temperature in the legs. Tobacco use,particularly cigar smoking,was associated with an increased risk of optic neuropathy.The risk was reduced among subjects with higher dietary intakes of methionine,vitamin B12,riboflavin,and niacin and higher serum concentrations of antioxidant carotenoids.The risk was also reduced among subjects who raised chickens at home or had relatives living overseas-factors that may be indirect measures of increased food availability.The epidemic of optic and peripheral neuropathy in Cuba between 1991 and 1993 appears to be linked to reduced nutrient intake caused by the country's deteriorating economic situation and the high prevalence of tobacco use. |
|