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We have performed a 14-month,prospective,randomized,double-blind,placebo- controlled study to evaluate the effect of deprenyl and levodopa/carbidopa (Sinemet)on the progression of signs and symptoms in patients with mild Parkinson's disease(PD).This study demonstrates that deprenyl attenuates deterioration in UPDRS score in patients with early PD.These findings are not readily explained by drug's symptomatic effects and are consistent with the hypothesis that deprenyl has a neuroprotective effect. |
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